Squamous cell skin cancer
Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma.[10] It usually presents as a hard lump with a scaly top but can also form an ulcer.[1] Onset is often over months.[4] Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer.[11]
The greatest risk factor is high total exposure to ultraviolet radiation from the Sun.[2] Other risks include prior scars, chronic wounds, actinic keratosis, lighter skin, Bowen’s disease, arsenic exposure, radiation therapy, poor immune system function, previous basal cell carcinoma, and HPV infection.[2][12] Risk from UV radiation is related to total exposure, rather than early exposure.[13] Tanning beds are becoming another common source of ultraviolet radiation.[13] It begins from squamous cells found within the skin.[14] Diagnosis is often based on skin examination and confirmed by tissue biopsy.[2][3]
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing squamous-cell skin cancer.[5][6] Treatment is typically by surgical removal.[2] This can be by simple excision if the cancer is small otherwise Mohs surgery is generally recommended.[2] Other options may include application of cold and radiation therapy.[7] In the cases in which distant spread has occurred chemotherapy or biologic therapy may be used.[7]
As of 2015, about 2.2 million people have cSCC at any given time.[8] It makes up about 20% of all skin cancer cases.[15] About 12% of males and 7% of females in the United States developed cSCC at some point in time.[2] While prognosis is usually good, if distant spread occurs five-year survival is ~34%.[4][5] In 2015 it resulted in about 51,900 deaths globally.[9] The usual age at diagnosis is around 66.[4] Following the successful treatment of one case of cSCC people are at high risk of developing further cases.[2]
Niagara Falls
Niagara Falls (/naɪˈæɡrə/ ny-ag-ra) is a city in Niagara County, New York, United States. As of the 2010 census, the city had a total population of 50,193, down from the 55,593 recorded in the 2000 census. It is adjacent to the Niagara River, across from the city of Niagara Falls, Ontario, and named after the famed Niagara Falls which they share. The city is within the Buffalo–Niagara Falls Metropolitan Statistical Area as well as the Western New York region.
While the city was formerly occupied by Native Americans, Europeans who migrated to the Niagara Falls in the mid-17th century began to open businesses and develop infrastructure. Later in the 18th and 19th centuries, scientists and businessmen began harnessing the power of the Niagara River for electricity and the city began to attract manufacturers and other businesses that were drawn by the promise of inexpensive hydroelectric power. After the 1960s, however, the city and region witnessed an economic decline following an attempt at urban renewal under then Mayor Lackey, consistent with the rest of the Rust Belt as industries left the city old line affluent families relocated to nearby suburbs and out of town.
Despite the decline in heavy industry, Niagara Falls State Park and the downtown area closest to the falls continue to thrive as a result of tourism. The population, however, has continued to decline from a peak of 102,394 in the 1960s due to the loss of manufacturing jobs in the area.